Vitamin B6 occurs in 3 forms–pyridoxine, pyridoxal, and pyridoxamine. B6 is absorbed in the large intestine. The muscle stores more or less 75-80 % of the vitamin even though the live stores approximately 5-10 %.

B6 is recommended for transaminations, ammonia release,, side chain cleavage reactions, dehydratases and decarboxylations. Its aldehyde group works as a Schiff base to react with the amino groups of amino acids. It basically acts to shuttle nitrogen between compounds.

Functions- The 3 kinds of B6 can all be converted on the coenzyme PLP which helps in transamination and protein metabolism. PLP is important for glycogen degradation; in addition, it will help with the development of the neurotransmitter, serotonin, the nonprotein part of hemoglobin (heme), nucleic acids, and lecithin. Vitamin B6 is important for the metabolic process of tryptophan to niacin.

Overall Reactions:

· Transaminations These reactions are necessary to recycle as well as reuse nitrogen in the body. They are the initial phase in amino acid catabolism and also the last stage in the synthesis of nonessential amino acids. Example: a-ketoglutarate + asparate glutamate + oxaloacetate

· Serine/ Threonine Deamination (Dehydratases) This response offers the production of the a keto acids of serine as well as threonine through oxidative removal of N as ammonia Example: Serine a-keto-serine + NH4+

· Decarboxylation These reactions often appear on the neuroactive amines of seratonin, tyramine, histamine, and GABA. They are undoubtedly critical in porphyrin synthesis, intermediates in the synthesis of sphingomyelin, taurine and lecithin, and for the breakdown and desulfuration of cysteine.

· Glycogen Phosphorylase 50 % of all B6 inside the body is certain to glycogen phosphorylase though the importance is unknown. The response is important for recycling of folate and is as follows:

Serine glycine + 5,10-methylene-THF

Deficiency Deficiencies of vitamin B6 are relatively rare. Individuals with a diet lacking in vitamin B6 will first show signs of weakness, nervousness, insomnia, irritability, and hydrated skin lesions. Far more advanced symptoms consist of growth failure, impaired motor function, hypochromic microcytic anemia, sleek tongue, as well as convulsions.

The impaired motor performance along with other psychological issues could be attributed to a reduction in amino acid-based neurotransmitters (serotonin, tyramine, GABA, epinephrine). You see an increase in urea excretion due to a decrease synthesis of nonessential amino acids. meal preps delivered from these amino acids is not recycled by transamination and instead is excreted as well as lost. You see an increase in urinary excretion particularly in the succeeding amino acids: metabolites of glycine, methionine, and tryptophan. The hypochromic microcytic anemia is simply because that there’s a reduced synthesis of the B6 dependent porphyrin ring of hemoglobin.

Individuals who are at most risk include the older folk with inadequate vitamin intake, hemodialysis patients, alcoholics, and those that are on drug therapy. General, individuals with a high metabolic stress.

Sources Foods richest in vitamin B6 include:

o whole grains o legumes o nuts o navy beans o walnuts o meat (sirloin plus chicken) o fish (salmon and shellfish) o bananas along with apples o broccoli and spinach

Therapeutics Vitamin B6 might provide healing benefits due to the following syndromes: carpal tunnel syndrome, glucose intolerance, sideroblastic anemia, neurologic disorders, hyperoxaluria, convulsive seizures, monosodium glutarate (MSG) intolerance, premenstral syndrome (pms) and Immune function. In addition, vitamin B6 may help to lower homocysteine levels and therefore the chance of acquiring cardiovascular disease.

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